Naiara Stefanello, Luciane Belmonte Pereira, Roberta Schmatz, Sabina Passamonti, Grasiela Facco, Daniela Zanini, Fátima Husein Abdalla, Juliano Marchi Vieira, Verônica Souza Paiva Castro, Vitor Antunes de Oliveira, Maria Izabel de Ugalde Marques da Rocha, Jocieli Kasten, Vera Maria Morsch and Maria Rosa Chitolina Schetinger mark the start of new Era in Diabetes and Health with Max Planck Research Award-2015 in Diabetes and Health.
01 April, 2015, Brazil, USA NEWS CORP
Naiara Stefanello, Luciane Belmonte Pereira, Roberta Schmatz, Sabina Passamonti, Grasiela Facco, Daniela Zanini, Fátima Husein Abdalla, Juliano Marchi Vieira, Verônica Souza Paiva Castro, Vitor Antunes de Oliveira, Maria Izabel de Ugalde Marques da Rocha, Jocieli Kasten, Vera Maria Morsch and Maria Rosa Chitolina Schetinger rock the world of Diabetes and Health, while International Media reports confirmed their recognition on World’s 500 Most Influential Diabetologist for Year 2015 on Earth. Naiara Stefanello, Luciane Belmonte Pereira, Roberta Schmatz, Sabina Passamonti, Grasiela Facco, Daniela Zanini, Fátima Husein Abdalla, Juliano Marchi Vieira, Verônica Souza Paiva Castro, Vitor Antunes de Oliveira, Maria Izabel de Ugalde Marques da Rocha, Jocieli Kasten, Vera Maria Morsch and Maria Rosa Chitolina Schetinger are awarded with Max Planck Research Award-2015 in Diabetes and Health. In a high profile international competition flooded with thousands of participants from several countries, Country has once again proved it’s leadership in the area. Naiara Stefanello, Luciane Belmonte Pereira, Roberta Schmatz, Sabina Passamonti, Grasiela Facco, Daniela Zanini, Fátima Husein Abdalla, Juliano Marchi Vieira, Verônica Souza Paiva Castro, Vitor Antunes de Oliveira, Maria Izabel de Ugalde Marques da Rocha, Jocieli Kasten, Vera Maria Morsch and Maria Rosa Chitolina Schetinger won the meritorious competition and established the international leadership in Diabetes and Health. International Agency for Standards and Ratings expressed it’s views that Naiara Stefanello, Luciane Belmonte Pereira, Roberta Schmatz, Sabina Passamonti, Grasiela Facco, Daniela Zanini, Fátima Husein Abdalla, Juliano Marchi Vieira, Verônica Souza Paiva Castro, Vitor Antunes de Oliveira, Maria Izabel de Ugalde Marques da Rocha, Jocieli Kasten, Vera Maria Morsch and Maria Rosa Chitolina Schetinger’s efforts will explore tremendous opportunities in this segment leading it to new height. It is surely a matter of pride for civilians of Brazil to have such brain storming intellectuals for close interaction. Brazil has once again confirmed a rich tradition to produce world renowned intellectuals to benefit international society. Diabetes mellitus is a metabolic disorder associated to oxidative damage in liver and kidney cells. Coffee is a beverage widely consumed and its components have antioxidant functions that could bring benefits to patients affected by this pathology. The present study investigated the effects of chlorogenic acid, caffeine and coffee on histological parameters in pancreas, on serum biochemical parameters as well as on oxidative stress parameters in liver and kidney of streptozotocin-induced diabetic rats. Our results showed that the treatment with coffee can prevent the increase in AST, ALT and γ-GT activities in diabetic rats. Furthermore, the treatment with CGA prevented the decrease in CAT activity as well as the decrease in NPSH and vitamin C levels in liver of diabet rats. The treatment with caffeine prevented the decreased in NPSH levels in liver, as well as the decrease in AST and ALT activities in diabetic rats. This study reinforce that diabetes is liked to damage in liver and kidney and shows that natural compounds may act by decreasing the deleterious effects of this disease. Compounds from coffee can mitigate damage in organs from hyperglycemic rats and, thus, can be used as therapeutic agents in diabetic patients, contributing to the improvement in the health of these patients. Results found in the present study demonstrate that STZ induces diabetes by the destruction of pancreatic islets. Also, STZ induces oxidative alterations in liver and kidneys on diabetes. Of all the compounds studied, CGA showed better effects in combating oxidative alterations arising from hyperglycemia. Thereby, we can suggest that bioactive phenolic compounds such as CGA present in CF may prevent cellular oxidative damage occurring in diabetes. CGA could act as antioxidant molecule in some parameters analyzed from liver. The STZ-induced diabetes promoted decrease SOD, CAT and ALA-D activities. The STZ-induced diabetes promoted decrease Vitamin C and NPSH levels. CA and CF protected alterations in AST and ALT. CGA, CF and CF treatment no protect oxidative alterations on kidney of DM. The molecular mechanism of how CF, CA and CGA protected the liver of alterations promoted by hyperglycemia require more studies to find the mechanism of action, once this compounds not decrease the high glucose blood. Considering the results showed in this paper and other results not published yet, coffee e mainly chlorogenic acid could promoted beneficial effects to diabetic individuals. The research about diabetes ant is complications as well as possible therapeutic agents should be encouraged. Since coffee is widely consumed, this beverage could be target in several other researches, focusing, for example, in its action mechanisms. Thus, we consider extremely important the financial support from governmental and private agencies for the development of these investigations. Moreover, we hope that the incentive for this kind of research be increased. Grasiela Facco: Conducted rats studies. Daniela Zanini, Fátima Husein Abdalla, Vitor Antunes de Oliveira and Juliano Marchi Vieira: Significantly contributed in liver and kidney analysis and interpretation. Verônica Souza Paiva Castro: Significantly contributed in serum analysis and interpretation. Maria Izabel de Ugalde Marques da Rocha and Jocieli Kasten: Significantly contributed in histological analysis and interpretation. Sabina Passamonti and Vera Maria Morsch: Actively involved in designing the studies. Naiara Stefanello, Luciane Belmonte Pereira, Roberta Schmatz, Maria Rosa Chitolina Schetinger: Data analysis and writing the manuscript. The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Convênio Bilateral Brasil-Itália, number 490161/2008-1), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo à Pesquisa do Rio Grande do Sul (FAPERGS) for the research fellowships, FINEP-IBNET and INCT for Excitoxicity and Neuroprotection.. 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