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Rahul R Deshpande, Ananth Kamath, Snehal Shep, Mayuri Mutha, Bhavana Metha, Dipti Patil, Rasika Torane and Nirmala Deshpande receive Robert Koch Research Award-2015 in Dentistry
16 March, 2015, India, USA NEWS CORP
Much awaited award was announced this week. Finally India wins Robert Koch Research Award-2015 in Dentistry. Thousands of nominations from several countries were received for international competition. The noble work is screened which distinguish from the rest, in different aspects of the Dentistry. The award is introduced to highlight excellent think tanks on global platform. The research findings were published on world’s prestigious The Journal for Dentistry. IASR recognized the researchers among world's 500 Most influential Dentist for the year 2015. Dr. Rahul R. Deshpande is Professor (BDS, MDS) at Department of Pediatric and Preventive Dentistry, Dr. D. Y. Patil Dental College and Hospital, Pune, Maharashtra, India. He is Consultant at Deenanath Mangeshkar Hospital, Pune, Maharashtra, India. Dr. Ananth Kamath is Reader (BDS, MDS) at Department of Pediatric and Preventive Dentistry, Dr. D. Y. Patil Dental College and Hospital, Pune, Maharashtra, India. Dr. Mayuri Mutha and Dr. Bhavana Metha are BDS, Post Graduate- MDS Part 2 at Department of Pediatric and Preventive Dentistry, Dr. D. Y. Patil Dental College and Hospital, Pune, Maharashtra, India. Dr. Snehal Shep and Dr. Dipti Patil are BDS, Post Graduate- MDS Part 1 at Department of Pediatric and Preventive Dentistry, Dr. D. Y. Patil Dental College and Hospital, Pune, Maharashtra, India. Dr. Rasika Torne, Ph.D is Faculty at Dr. T. R. Ingle Research Laboratory, Department Of Chemistry, S. P. College, Pune, Maharashtra, India. There has been an increase in the demand for newer antimicrobial agents to combat prevalent microbial diseases of oral tissues due to rapid emergence of multidrug‐resistant pathogens and many drawbacks of synthetic chemotherapeutic drugs. This study aims to comparatively evaluate the antimicrobial efficacies of herbal extracts of Morinda pubescens and Ehretia laevis against salivary microflora and with a standard synthetic chemotherapeutic agent, to support use of natural herbs’ formulations as preventive and therapeutic agents. Their efficacy was evaluated by performing antimicrobial assay on patient saliva samples. It was observed that all the extracts have marked activity against the tested microorganisms with the acetone extract of M. pubescens and derived Compound 5 of ethanol extract of E. leavis showing maximum antimicrobial activity with larger zones of inhibition at used concentrations. This paper primarily focuses on a comparison between these two extracts, and it shows that extracts of E. leavis have higher antimicrobial activity than M. pubescens extracts at lower concentrations, but at higher concentrations M. pubescens shows larger zones of inhibitions. The effect of these plants on more pathogenic organisms, evaluation of further higher concentrations for toxicological investigations and further purification however needs to be carried out. This comparative study indicates that the derivative compound 5 of crude ethanol extract obtained from leaves extract of Ehrita laevis was found to be more effective anti-microbial agent at lower concentrations than highly active acetone extract of Morinda pubescens, against the salivary microflora. At higher concentrations though, both plant extracts might show similar activity, which can be evaluated with further assay of these extracts. The study also confirmed the antimicrobial potentials of both the plants, thus supporting its folklore application as a preventive remedy for various microbial diseases of hard and soft tissues in the oral cavity. The findings of the present investigation offer a scientific support to the ethnomedicinal use of these plants by the traditional healers. This research aims to develop newer effective and efficient antimicrobial agents with minimal side effects which would prove to be an alternative to currently being used synthetic antimicrobials. In the dentistry, these effective plant extracts can be formulated into preparations such as dentifrices, mouth washes, gum paints or as an intra-canal medicament and may be used where an antimicrobial agent is required. This research would help support the use of natural herbs, as medicine, which is already in a great demand in developing world. This investigation opens up the possibility of the use of these plants in drug development for human consumption possibly for the preventive and therapeutic needs in dentistry. The effect of these plants on more pathogenic organisms is yet to be evaluated. In this study the herbal extracts of said medicinal plants are tested at lower concentrations, evaluation of further higher concentrations for toxicological investigations and further purification however needs to be carried out. Agharkar Research Institute, Pune, India and Deshpande’s Oral Health Clinic, Pune, India were acknowledged for award winning study.
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